New Publications
“Differential Anti-Inflammatory Effects of Electrostimulation in a Standardized Setting”
https://pubmed.ncbi.nlm.nih.gov/39337300/
“Modified Methylation Following Electrostimulation in a Standardized Setting-Complementing a Transcriptomic Analysis”
https://pubmed.ncbi.nlm.nih.gov/40498014/
Short Description
Clinical application of physical stimuli, in particular in anti-inflammatory key, is poorly explored due to the fragmentation of the research area, the lack of standardized systems and (as a consequence) the possibility to conduct meta-analyses and infer dose-response relationships.
To address these concerns, we devised a 3D bioconstruct (fibroblasts and keratinocytes in a collagen matrix) to test systematically the effect of direct and alternate electrical current, and varying intensities. We analyzed three layers of omics to explore the differential impact of the stimulus characteristics and their impact in inflamed or physiological environments.
We observe very diverse responses going from anti-inflammatory to transitional activity (i.e., referred to the process associated with a transition from a state to another), indicating that not only the impact of such stimuli is relevant also in very simple constructs – notably in the absence of nervous system-, but that dose and pre-existing environment are important to determine the final outcome.
Review
https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.70129
This review recollects for the first time a description of the main known molecular effectors involved in four physical transduction phenomena (electric, mechanic, magnetic and optic), their potential overlap, and how network theory, and in particular the research framework of network medicine, can be instrumental to include these stimuli in the pharmacological panoply of anti-inflammatory options.
From intuitive networks reporting the complexity of multiple biochemical interactions, to network embedding typical of artificial intelligence algorithms, this review gives an original viewpoint on the potential and acquired benefits that can be obtained from applying network medicine to the poorly explored field of physical transduction.