Boraschi – CIN – CNR Immunology Network

Mechanisms of activation and polarisation of human monocytes and macrophage-derived macrophages
Mechanisms of induction and modulation of innate memory of monocytes and macrophages
Role of inflammatory cytokines in chronic inflammatory, immune-related and degenerative diseases
Biology of IL-1 family cytokines
Immunosafety of engineered nanoparticles, with focus on innate immunity, inflammation, and innate memory.
Evaluation of innate memory induction and modulation in the marine invertebrate Ciona intestinalis
In vitro tissue-like 3D models for studying human macrophage functions.

Principali progetti e partners

Partners

Lab with the Lab of Invertebrate Immunology and Nanosafety (Institute for Biomedical Research and Innovation – IRIB-CNR, Head: Dr Annalisa Pinsino)
Joint Lab with the Lab of Evolution of Immune System (Institute of Biochemistry and Cell Biology – IBBC-CNR, Head: Dr Maria Rosaria Coscia)
University of Salzburg
University of Pisa
University of Catania
Catalan Institute of nanoscience and nanotechnology
Stazione Zoologica “Anton Dohrn”
• European Commission, Joint Research Centre, Ispra (IT)

Progetti

PRIN 2017 “NanoTechVax Tackling biological barriers to antigen delivery by nanotechnological vaccines”. Prot. 20173ZECCM.
H2020 ETN project “ENDONANO: Quantitative detection of bacterial ENDOtoxin by novel NANOtechnological approaches”. H2020-MSCA-ITN-2018 – EID- 812661.
PNRA 2018 “Impact of the Antarctic environments on human homeostasis, psychology, physiology and immunology”
PNRA 2016 “Effects of extreme environments on psychophysiology, energy metabolism and immunity: neuropsychological, immunohistochemical, proteomic and fMRI studies”

Strumenti / Tecnologie

Cell isolation and culture
Gene expression (real-time PCR)
Functional & immunochemical assays
FACS facility
Imaging facility (confocal, live imaging, correlative microscopy, electron microscopy
MS facility for proteins, small molecules, lipids and glycans