Antibody response

Group Leader
Maria Rosaria Coscia


Istituto di Biochimica e Biologia Cellullare
Via Pietro Castellino 111 , 80131 Napoli
Tel. 0816132273

Membri del Laboratorio

Alessia Ametrano (PhD student);
Marianna Maffia (Undergraduate student);
Umberto Oreste (Associate Researcher Emeritus)


Strumenti / Tecnologie

Our main research activity is focused on: i) the Evolution of immunoglobulin genes from Antarctic teleost species; ii) the impact of the environmental stress conditions, such as those of the Antarctica, on human humoral immune response; iii) the design and production of engineered high performance antibodies as innovative diagnostic/therapeutic tools, using the CRISPR-Cas9 technology.

To address these questions, our group has chosen a multidisciplinary approach combining Molecular and Cell Biology, Biochemistry and Bioinformatics.

Molecular cloning, genome editing, gene expression (real-time PCR). Biochemical equipment available at the IBBC Core Facilities: HPLC, FPLC, Light scattering, Molecular Imager Gel-Doc XR System spectrophometers, MS facility for proteins, small molecules, lipids and glycans.

Principali progetti e collaborazioni

PNRA Project PNRA16_00047-A2 “Effects of extreme environments on psychophysiology, energy metabolism and immunity: neuropsychological, immunohistochemical, proteomic and fMRI studies” 

PNRA Research Project PNRA18_00071-F-Concorde “Impact of the Antarctic environment on human homeostasis, psychology, physiology and immunity”