Giuseppe Matarese

The Laboratory of Prof. Matarese has focused, over the last 15 years, on the study of the cellular and molecular mechanisms that regulate the basic principles of immunological tolerance and how the immune system is able to discriminate the self – from non-self. We also have an increasing interest in the understanding of the relationship among immune system, metabolism and inflammation both in normal conditions and autoimmune diseases, such as Multiple Sclerosis (MS) and Type I Diabetes (T1D). In these processes, the biology of regulatory T cells, a specific cellular subset involved in the control of immunological tolerance, is one of the cornerstones of investigation in our laboratory. We also study the main intracellular metabolic pathways and the molecular programs needed for the generation of functional Tregs cells in physiological as well as pathological conditions.