Immunopharmacology of natural substances
Group Leader
Maria Pia Fuggetta
- 39-06-49934610 - 4259
- mariapia.fuggetta@ift.cnr.it
- Sito web istituzionale
Istituto
Istituto di Farmacologia Traslazionale
Via Fosso del Cavaliere 100 – 00133 Roma
Tel. +39 06 45488486
http://www.ift.cnr.it
Membri del Laboratorio
Prof. Enzo Bonmassar,
Senior Research Associate
bonmasse@yahoo.com
Prof. Giampiero Ravagnan
Senior Research Associate
ravagnangp@gmail.com
Attività
- Effects of drugs and natural substances on Cell Mediated Immunity: CTL/NK cytotoxicity
- Drug-induced Neoantigens on tumour cells (Xenogenization,DIX) Antigen specific recognition by CTL
- Control of inflammation by natural substances : in vitro models of inflammation and Inflammation in obesity (model of obesity in vitro)
- Immunologyc effects of Resveratrol/Polydatin (Spinoff) • Effects of new inhibitors of the "Inflammasome-Caspase-1
- Effects of new inhibitors of the "Inflammasome-Caspase-1 Complex" new molecules which, by inhibiting Interleukin -1β, can control autoimmune and inflammatory disorders (collaboration with ICB/CNR Sassari )
- In vitro tumor growth(apoptosis telomerase activity)
- In vitro cellular immunology
- NK and CTL cytotoxic activity (Test 51Cr release- or colorimetric)
- In vitro model of cell/cell interaction (cellular cross talk)
- Immune Cell separation
- ELISPOT
- Cytokines production (TEST ELISA)
- Western blot
Altre Informazioni
Academic SPINOFF www.glures.it
PATENTS:
2 international patents: (PCT / IB01 / 00983) and (PCT / IB2001 / 00981) concerning the extraction methods and the antitumor and immunomodulatory effects of Resveratrol and its glucoside derivative POLYDATIN . The patents were the basis of the academic SPINOFF, participated CNR, represented by GLURES srl company. The patent (PCT / IB01 / 00983) has been licensed for use and has resulted in the marketing of Polydatin-based products: a “supplement for special medical purposes” containing 100% Polydatin and a dermocosmetic product.
Clinical studies are in progress