Drug Discovery
Group Leader
Michele Saviano
- 39-0805929148
- michele.saviano@cnr.it
- Sito web istituzionale
Istituto
Istituto di Cristallografia
via Amendola 122/O, 70126 BARI
Tel. +39-0805929148
http://www.ic.cnr.it
Membri del Laboratorio
Maria Moccia (Ricercatore)
Stefania De Luca (Ricercatore)
Emma Langella (Ricercatore)
Rocco Caliandro (Ricercatore)
Attività
- Selection and validation of ligands highly specific for HER2 receptor, derived from the Herceptin Fab region
- Drug design of miniaturized antibodies
- Antisense peptide nucleic acid (PNA)
- Processing of Monoclonal Antibodies by Continuous Template-Assisted Membrane Crystallization for Industrial Production
Strumenti / Tecnologie
- Peptide Synthesis and Purification (solid state and solution synthesis, HPLC)
- Biophysical characterization (Circular Dichroism; Dynamic Light Scattering, fluorescence spectroscopy, Isothermal Titration Calorimetry; Surface Plasmon Resonance, Nuclear Magnetic Resonance)
- X-ray diffraction analysis on single crystals
- Macromolecular X-ray crystallography at synchrotron radiation sources
- Small angle X-ray scattering in solution at synchrotron radiation
- Drug Design and Biocomputing simulations (molecular dynamics, docking, virtual screening)