Laboratory of Organic Synthesis and Bioactive Molecules (Syn@BioMol)

Group Leader
Pietro Spanu


Isituto di Chimica Biomolecolare
S.S. Sassari
Traversa La Crucca, 1, 07100 San Giovanni SS
Tel. +39 0792841203

Membri del Laboratorio

Dr Pietro Spanu (I ric)    

Dr. Fausta Ulgheri (ric)  

Dr. Francesco Deligia

Dr. Maria Cristina Porcu (tecnico)



We are interested in the role of innate immune activation and inflammation in the pathogenesis of major neurodegenerative diseases. Our targets are new small molecules able to modulate inflammatory processes useful in the therapy of neurological disorders, and we are working on design, synthesis and characterization of new caspase-1 inhibitors as lead compounds for neurodegenerative diseases. We discovered a new class of selective, non-covalent, non-peptidic caspase-1 inhibitors that mediate neuroprotection against glutamate toxicity and are able to cross the blood-brain-barrier.

Strumenti / Tecnologie

NMR, HPLC,MCR and asymmetric synthesis

Altre Informazioni

Collaborations: Prof. Alexander Doemling, Dr. Maria Pia Fuggetta IFT-CNR