Laboratory of Organic Synthesis and Bioactive Molecules (Syn@BioMol)
Group Leader
Pietro Spanu
- 079 2841221
- 0792841222
- p.spanu@icb.cnr.it
- Sito web istituzionale
Istituto
Isituto di Chimica Biomolecolare
S.S. Sassari
Traversa La Crucca, 1, 07100 San Giovanni SS
Tel. +39 0792841203
http://www.icb.cnr.it/
Membri del Laboratorio
Dr Pietro Spanu (I ric) p.spanu@icb.cnr.it
Dr. Fausta Ulgheri (ric) f.ulgheri@icb.cnr.it
Dr. Francesco Deligia francesco.deligia@ss.icb.cnr.it
Dr. Maria Cristina Porcu (tecnico) cristina.porcu@ss.icb.cnr.it
Attività
We are interested in the role of innate immune activation and inflammation in the pathogenesis of major neurodegenerative diseases. Our targets are new small molecules able to modulate inflammatory processes useful in the therapy of neurological disorders, and we are working on design, synthesis and characterization of new caspase-1 inhibitors as lead compounds for neurodegenerative diseases. We discovered a new class of selective, non-covalent, non-peptidic caspase-1 inhibitors that mediate neuroprotection against glutamate toxicity and are able to cross the blood-brain-barrier.
NMR, HPLC,MCR and asymmetric synthesis
Collaborations: Prof. Alexander Doemling, Dr. Maria Pia Fuggetta IFT-CNR