Pediatric Allergy and Pulmonology (PAP)

Group Leader
Stefania La Grutta


Istituto per la Ricerca e l’Innovazione Biomedica

Via Ugo La Malfa, 153 – 90146 Palermo
Tel. +39 0503757523

Membri del Laboratorio

Velia Malizia, M.D. (COCOCO)

Laura Montalbano, Psychologist (doctorate fellow)

Giovanna Cilluffo, statistician (doctorate fellow)

Salvatore Fasola, statistician (COCOCO)


Outpatient clinic for asthma and allergic rhinitis management and education. Pediatric Severe Asthma Center for state of the art evaluation and treatment options for children and adolescents with severe or difficult to control asthma. Phase II and III clinical trials. Lung function tests. Assessment of non invasive inflammatory pathways (lung and nose exhaled nitric oxide determination; skin prick tests for common allergens). Evaluation of early biomarkers involvement in immunological and molecular mechanisms underlying progression of inflammation in childhood asthma and rhinitis. Collaboration in translational researches with IBIM biologists

Strumenti / Tecnologie

Spirometry for lung function screening with module for the measurement of airway resistance (Rocc) through the interruper technique;
Microrint to measure airways resistance and the calibre of the airway using the interrupter technique through an effort independent test;
Forced Oscillation Technique (FOT) for measuring total respiratory system impedance in children during spontaneous breathing (presence and extent of expiratory flow limitation and heterogeneity of the obstruction);
Instrument for Functional residual capacity (FRC) and ventilation inhomogeneity (LCI) measurements during normal tidal breathing by Multiple Nitrogen Washout for infant and preschool children;
FeNO measurements to detect airway inflammation at different levels of the respiratory tract (bronchial, alveolar, nasal) by multiple and single breath technique;
Nasal citology to determine the inflammatory pattern (rhinocytogram) of nasal disorders in children for the diagnostic work-up of nasal disorders in children.