abruzzo

Group Leader : Daniela Piancatelli

• +39-0862-318843
• daniela.piancatelli@cnr.it
  

Institute
Institute of Translational Pharmacology (IFT), L’Aquila section
Via Carducci 32,  6710 –  L’ Aquila
http://www.ift.cnr.it/

Lab members

Anna Aureli anna.aureli@cnr.it
Angelica Canossi angelica.canossi@cnr.it
Daniela Piancatelli daniela.piancatelli@cnr.it

Activities

HLA polymorphism in transplantation and diseases, polymorphisms of non classical HLA and HLA-related loci; HLA-G 3’UTR polymorphisms. Immunogenetics of developmental neurological disorders, cancer, celiac disease and diseases of immunological and metabolic interest. Tolerance and immune dysregulation in kidney  transplantation. Immunosurveillance of suppressive molecules in the post-transplant period of kidney transplant recipients for early prediction of acute rejection and renal dysfunction (liquid biopsy). Role of Fc γ receptor and KIR/HLA in cancer and degenerative diseases. Characterization of novel alleles. Population genetics.

CIN website:

D. Piancatelli – Classical and non-classical HLA, immunogenetics of transplantation and diseases; population genetics.
A. Aureli – Fc receptors, CD1 and BDNF in cancer and diseases.
A. Canossi – Immunosurveillance of suppressive molecules in kidney transplant recipients for early prediction of acute rejection and renal dysfunction (liquid biopsy).

Key words
Immunogenetics, HLA, transplantation, cancer

Key publications 

• Impact of HLA Class I Antigen, Killer Inhibitory Receptor, and FCGR3A Genotypes on Breast Cancer Susceptibility and Tumor Stage. Canossi A, Aureli A, Del Beato T, Novelli G, Buonomo O, Rossi P, Venditti A, Papola F, Sconocchia G. Curr Mol Med. 2024;24(7):920-930. doi: 10.2174/1566524023666230717162458.
• Longitudinal monitoring of mRNA levels of regulatory T cell biomarkers by using non-invasive strategies to predict outcome in renal transplantation. Canossi A, Iesari S, Lai Q, Ciavatta S, Del Beato T, Panarese A, Binda B, Tessitore A, Papola F, Pisani F. BMC Nephrol. 2022 Feb 2;23(1):51. doi: 10.1186/s12882-021-02608-3.
• CD1 gene polymorphism and susceptibility to celiac disease: Association of CD1E*02/02 in Moroccans. Aureli A, Aboulaghras S, Oumhani K, Del Beato T, Sebastiani P, Colanardi A, El Aouad R, Ben El Barhdadi I, Piancatelli D. Hum Immunol. 2020 Jul;81(7):361-365. doi: 10.1016/j.humimm.2020.05.005.
• Breast Cancer Is Associated with Increased HLA-DRB1*11:01 and HLA-DRB1*10:01 Allele Frequency in a Population of Patients from Central Italy. Aureli A, Canossi A, Del Beato T, Buonomo O, Rossi P, Roselli M, Papola F, Marziani B, Sconocchia G. Immunol Invest. 2020 Jul;49(5):489-497. doi: 10.1080/08820139.2020.1737539.
• HLA-G14bp ins/del polymorphism and post-transplant weight gain in kidney transplantation: potential implications beyond tolerance. Piancatelli D, Maccarone D, Colanardi A, Sebastiani P, Clemente K, Iesari S, Lai Q, Pisani F. BMC Nephrol. 2020 Mar 30;21(1):109. doi: 10.1186/s12882-020-01752-6.

Instruments/Technologies

Sequence-based typing, genotyping/allelic discrimination, gene expression (RT-PCR), cell cultures, ELISA.