Structural Biology

Group Leader
Sonia Covaceuszach

Istituto

Istituto di Cristallografia
Area Science Park –   S.S. 14 Km 163.5 BASOVIZZA 34149 TRIESTE (IT)
Tel. +39 0503757523
http://www.ic.cnr.it

Membri del Laboratorio

Alberto Cassetta (Ricercatore) alberto.cassetta@ts.ic.cnr.it);

Alessandro Pesaresi (Ricercatore) alessandro.pesaresi@ts.ic.cnr.it

Doriano Lamba (Primo Ricercatore) doriano.lamba@ts.ic.cnr.it

Attività

  • Structural and functional studies of neurotrophins and pro-neurotrophins
  • Neurotrophins and pro-neurotrophins interactions with endogenous ligands (ATP, lipids, metals, etc.) and with neutralizing antibodies
  • Structure-based humanization of antibodies

Strumenti / Tecnologie

  • Cloning and heterologous proteins expression (E.coli); Protein refolding; Protein purification
  • Proteins biophysical characterization (Circular Dichroism; Dynamic Light Scattering, Differential Scanning Fluorimetry, Isothermal Titration Calorimetry; Surface Plasmon Resonance
  • High throughput crystallization screening
  • Macromolecular X-ray crystallography at synchrotron radiation sources
  • Small angle X-ray scattering in solution at synchrotron radiation sources
  • Biomolecular simulations (molecular dynamics, docking, virtual screening)